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Gonadotropin Releasing Hormone Receptor (GnRHR)

Gonadotropin Releasing Hormone Receptor (GnRHR)

Cat no: G8576-01A

Supplier: United States Biological
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Gonadotropin Releasing Hormone (GnRH) is down-regulated by hCG and believed to be an autocrine factor that regulates the ovary. The Gonadotropin Releasing Hormone Receptor (GnRHR) is synthesized in the pituitary gland. Activin A has been shown to stimulate the synthesis of GnRHR, illustrating a possible mechanism for the modulation of gonadotropin responsiveness to GnRH. GnrH functions as a stimulator of gonadotrophs to release luteinizing hormone (LH) and follicle stimulating hormone (FSH) Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry: 1:200 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8576-01A
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Mab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Pask AJ, et al. A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation. Mol. Endocrinol. Apr 2005; 19 (4): 972-981.
Additional info: Recognizes human Gonadotropin Releasing Hormone Receptor. Reacts with GnrH receptors in the anterior pituitary.

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