Gp130, Human, BioAssay(TM) MAP Kit (CD130, IL6ST)

Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.\n\nSample Type:\nCell culture supernates, serum, EDTA plasma, and heparin plasma.\n\nSensitivity:\nThe mean MDD was 12.0pg/ml. The Minimum Detectable Dose (MDD) was determined by adding two standard deviations to the MFI of twenty zero standard replicates and calculating the corresponding concentration. \n\nRange:\n~4.96-21pg/ml\n\nSpecificity:\nRecognizes natural and recombinant human gp130. \n\nTest Principle:\nHuman gp130 BioAssay(TM) Kit afford the user the benefit of multianalyte analysis of biomarkers in a complex sample. For each sample type, a single, multipurpose diluent is used to optimize recovery, linearity, and reproducibility. Such a multipurpose diluent may not optimize any single analyte to the same degree that a unique diluent selected for analysis of that analyte can optimize conditions. Therefore, some performance characteristics may be more variable than those for assays designed specifically for single analyte analysis.\n\nKit Components:\nMicroparticle Concentrate, 100X concentrated, 1x0.075ml\nBiotin-Antibody Concentrate, 100X concentrated, 1x0.075ml\n\nStorage and Stability:\nStore powder at 4 degrees C liquid at -20 degrees C. Store other components at 4 degrees C. Stable for at least 6 months For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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