GPR143 Antibody

Cat no: 252189

Supplier: ABBIOTEC

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Description
Additional Information

G-protein coupled receptor 143 (GPR143) is a receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, GPR143 stimulates Ca2+ influ, Xenopus/Amphibian, into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane. This ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. The activity of GPR143 is mediated by G proteins which activate the phosphoinositide signaling pathway. GPR143 also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. Defects in GPR143 are the cause of albinism ocular type 1 (OA1), also known as Nettleship-Falls type ocular albinism. This is a form of albinism affecting only the eye. Pigment of the hair and skin is normal or only slightly diluted.

Catalogue number:	252189
Reactivities:	Human
Applications:	Western Blot
Size:	0.1 mg
Accession:	P51810
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GPR143.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	G-protein coupled receptor 143; Ocular albinism type 1 protein; GPR143; OA1