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GPR15, NT (G-protein Coupled Receptor 15, Brother of Bonzo, BoB)

GPR15, NT (G-protein Coupled Receptor 15, Brother of Bonzo, BoB)

Cat no: G8585-01A

Supplier: United States Biological
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Human immunodeficiency virus (HIV) and related viruses require co-receptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV co-receptors. The genes encoding human and monkey GPR15/BOB (for G protein-coupled receptor 15 and brother of Bonzo, respectively,) were recently cloned. This novel G protein-coupled receptor serves as co-receptor for simian immunodeficiency virus (SIV), and for strains of HIV-2 and M- tropic HIV-1. The ligand for GPR15 has not been identified yet. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human spleen tissue lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8585-01A
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Heiber, M. et al. Genomics 32, 462 (1996). 2. Deng, HK. et al. Nature 388, 296 (1999). 3. Farzan, M. et al. J Exp. Med. 186, 405 (1997).
Additional info: Recognizes human GPR15. Species Crossreactivity: mouse and rat.

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