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GPR35 (G Protein Coupled Receptor 35, GPCR35, Kynurenic Acid Receptor, KYNA Receptor)

GPR35 (G Protein Coupled Receptor 35, GPCR35, Kynurenic Acid Receptor, KYNA Receptor)

Cat no: G8600-39M

Supplier: United States Biological
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GPR35 initially identified as an orphan G-protein coupled receptor, was recently deorphanized using high-throughput intracellular calcium measurements in clonal cell lines expressing a chimeric G-protein alpha-subunit. Recent studies confirm kynurenic acid, a tryptophan metabolite, as a ligand for GPR35. The protein shares homology with purinergic P2Y receptors, lysophosphatidic acid receptor GPR23, nicotinic acid receptor HM74, and the cannabinoid receptor GPR55. Expression analysis revealed prominent expression of the protein in immune and gastrointestinal tissues, suggesting potential physiological roles for GPR35 in these organs. The potential role of the protein involves regulating neuronal excitability and synaptic release. The protein has also been reported as a potential oncogene implicated in gastric cancer. The gene encoding for human GPR35 is localized in the chromosomal region 2q37.3. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunofluorescence: 5ug/ml Western Blot: 0.5-1ug/ml Immunocytochemistry: 5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: MCF7 and Raw cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8600-39M
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunocytochemistry, Immunofluorescence, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Jinghong, W. et al. J. Biol. Chem. 281:22021-22028 (2006). 2. Hiroyuki, O. et al. Biochemical and Biophysical Research Communications. 365:344-348 (2008). 3. Guo, J. et al. J. Pharmacol. Exp. Ther. 324:342-351 (2008).
Additional info: Recognizes human G Protein-Coupled Receptor GPR35. Species Crossreactivity: mouse.

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