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GPR72 (GPR83, Probable G-protein Coupled Receptor 83, G-protein Coupled Receptor 72, KIAA1540)

GPR72 (GPR83, Probable G-protein Coupled Receptor 83, G-protein Coupled Receptor 72, KIAA1540)

Cat no: G8600-76M

Supplier: United States Biological
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G-protein coupled receptor 83 (GPR83, GIR, GPR72, KIAA1540), a 423aa protein, is an orphan member of GPCR protein family and is closely related to tachykinin and NPY receptors. It is a human homolog of mouse GIR protein and is exclusively expressed and selectively up-regulated in brain. It is a cell surface receptor protein consisting of a putative seven-transmembrane-domain. Reports suggest GPR83 might be involved in the regulation of immune tolerance mechanism by inducing peripheral generation of Foxp3+ Treg cells. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.1-1ug/ml Immunohistochemistry (frozen, formalin fixed paraffin embedded): 20ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8600-76M
Reactivities: Human, Mouse, Rat, Bovine, Canine, Chicken/Bird
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Moerlooze et.al Cytogenet Cell Genet 90 (1-2) 146-150 (2000) 2. Hansen et.al J Immunol 177; 209-215 (2006).
Additional info: Recognizes human GPR83. Species Crossreactivity: bovine, chicken, canine, mouse, rat, rhesus monkey. Species sequence homology: xenopus, chicken.

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