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GPR77 (G Protein-Coupled Receptor 77, C5L2, C5a Anaphylatoxin Chemotactic Receptor C5L2)

GPR77 (G Protein-Coupled Receptor 77, C5L2, C5a Anaphylatoxin Chemotactic Receptor C5L2)

Cat no: G8600-81F

Supplier: United States Biological
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C5L2 is 337aa orphan member that belongs to anaphylatoxin receptor family. It is a seven transmembrane G-protein-coupled receptor consisting of an N-terminal N-glycosylation site, several conserved cysteines and several potential C-terminal phosphorylation sites. It binds to C5a and C5a-des-Arg and serves as a highly regulated scavenger receptor with a negative modulatory influence on C5aR-mediated inflammation. Northern Blot analysis suggests it is co- expressed along with C5aR in different tissues and cells including neutrophils:macrophages, mast cells, dendritic cells, brain, lung, heart, kidney, liver, ovary and testis. Applications: Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunohistochemistry (paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human testis cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8600-81F
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Johswich et.al JBC 281 (51) 39088-39095 (December 22, 2006).
Additional info: Recognizes human GPR77. Species Crossreactivity: chimpanzee. Species sequence homology: bovine, rhesus monkey.

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