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GPR83 (Probable G-protein Coupled Receptor 83, G-protein Coupled Receptor 72, GPR72, KIAA1540)

Cat no: G8600-76N

GPR83 (Probable G-protein Coupled Receptor 83, G-protein Coupled Receptor 72, GPR72, KIAA1540)

G-protein coupled receptor 83 (GPR83, GIR, GPR72, KIAA1540), a 423aa protein, is an orphan member of GPCR protein family and is closely related to tachykinin and NPY receptors. It is a human homolog of mouse GIR protein and is exclusively expressed and selectively up-regulated in brain. It is a cell surface receptor protein consisting of a putative seven-transmembrane-domain. Reports suggest GPR83 might be involved in the regulation of immune tolerance mechanism by inducing peripheral generation of Foxp3+ Treg cells.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:2000\nWestern Blot: 1-3ug/ml, human brain (cerebellum, cerebral cortex and amygdala) lysates observed on ~50kD bands\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G8600-76N

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Additional Info

Recognizes human GPR83.

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