Home  >  Products  >  Gr-1 (GR1, Myeloid Differentiation Antigen, Lymphocyte Antigen 6 Complex Locus G, Lymphocyte Antigen 6G, Ly6g, Ly-6G, Ly-6G.1)
Gr-1 (GR1, Myeloid Differentiation Antigen, Lymphocyte Antigen 6 Complex Locus G, Lymphocyte Antigen 6G, Ly6g, Ly-6G, Ly-6G.1)

Gr-1 (GR1, Myeloid Differentiation Antigen, Lymphocyte Antigen 6 Complex Locus G, Lymphocyte Antigen 6G, Ly6g, Ly-6G, Ly-6G.1)

Cat no: G8750-01A2

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
The Gr-1 antigen is a 21-25kD cell surface protein that belongs to the Ly-6 family of proteins. The Gr-1 antigen is primarily a marker of myeloid differentiation. In the bone marrow the level of Gr-1 expression is low on immature myeloblasts and increases as the myeloid cells mature to granulocytes. Gr-1 is also expressed on macrophages and transiently on differentiating monocytes. Expression of Gr-1 on a subpopulation of lymphocytes has also been reported. Applications: Suitable for use in Flow Cytometry, Immunohistochemistry, Immunoprecipitation and Westen Blot. Reported to deplete mouse mature neutrophils in vivo. Catalog #G8750-01A1 is recommended for functional studies. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:100-1:200; 10ul labels 10e6 cells in 100ul. Immunohistochemistry: Frozen sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8750-01A2
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein G affinity chromatography.
References: 1. Fleming, T.J., et al., J. Immunol. 151: 2399-2408 (1993). 2. Hestdal, K., et al., J. Immunol. 147: 22-28 (1991). 3. Czuprynski, C.J., et al., J. Immunol. 152: 1836-1846 (1994). 4. Sumagin, R., et al., J. Immunol. 185: 7057-7066 (2010). 5. Takano, K., et al., J. Pharmacol. Exp. Ther. 336: 381-390 (2011). 6. Giroux, M., et al., Blood 117: 1734-1744 (2011). 7. Suttmann, H., et al., Cancer Res. 66: 8250-8257 (2006). 8. Nix, R.N., et al., PLoS Pathog. 3: e193 (2007). 9. Kanda, N., et al., Endocrinology 152: 3155-3164 (2011).
Additional info: Recognizes mouse Gr-1 antigen. Reacts predominantly with the Ly-6G protein but weaker reactivity with the Ly-6C protein has been demonstrated.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave