Granulocyte Macrophage Colony Stimulating Factor (GM-CSF, Burst Promoting Activity, CMCSF, Colony Stimulating Factor 2, CSF Alpha, Eosinophil Colony Stimulating Factor, Granulocyte Macrophage Colony Stimulating Factor, Molgramostin, Pluripoietin Alpha, Sa

GM-CSF is a 23kD glycoprotein with diverse effects on immune and non-immune cells. It induces differentiation of granulocyte, macrophage and eosinophil precursor cells. Proliferation of monocyte-macrophages, T lymphocytes, keratinocytes and endothelial cells is stimulated by GM-CSF. In addition, GM-CSF alters the functional properties of mature granulocytes, macrophages, eosinophils and basophils. GM-CSF is produced by T lymphocytes, macrophages and several cell types in extreme dullary sites, where it may act in a paracrine manner to regulate the local response to antigenic challenge. \n \nApplications:\nSuitable for inhibition of biological activity of GM-CSF in functional studies and for immuno assay, Western Blot, Immunoprecipitation, and Immunohistochemistry (frozen). Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:10\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at-20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with 0.5 ml sterile distilled or de-ionized water . Aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

G8951-25C

Size

100ug

Applications

IHC, IP, WB

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a lyophilized powder in PBS. Reconstitute the vial by injection of 0.5 ml sterile distilled or de-ionized water (Caution: vial is under vacuum).

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG2a

References

1. O'Garra, A et al; The BCL1 B lymphoma responds to IL-4, IL-5, and GM-CSF. Cell Immunol 1989, 123: 189 2. Ruef, C et al; Granulocyte-macrophage colony-stimulating factor: pleiotropic cytokine with potential clinical usefulness. Rev Infect Dis 1990, 12: 41

Additional Info

Recognizes natural and recombinant mouse GM-CSF. It inhibits the induction of the proliferation of BCL1 cells by GM-CSF.

Alternative Names

GM-CSF, colony stimulating factor, sargamostin, granulocyte-macrophage colony stimulating factor