Granulocyte Macrophage Colony Stimulating Factor, Recombinant, Human (GM-CSF, Burst Promoting Activity, CMCSF, Colony Stimulating Factor 2, CSF Alpha, Eosinophil Colony Stimulating Factor, Granulocyte Macrophage Colony Stimulating Factor, Molgramostin, Pl

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages. It promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity.\n\nRecombinant human GM-CSF is a 14.6kD globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.\n\nBiological Activity:\nGM-CSF is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is (same/less than) 0.1ng/ml, corresponding to a specific activity of (same/more than) 1x10e7 units/mg.\n\nResponding Cells (Partial List):\nCertain BM precursor cells\n\nStorage and Stability:\nLyophilized powder may be stored at 4 degrees C for short-term only. Reconstitute to nominal volume by adding sterile ddH2O, aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer\n\nCountry of Origin:\nUSA

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SPECIFICATIONS

Catalog Number

G8950-10

Size

5ug

Form

Supplied as a sterile-filtered, lyophilized powder from 10mM sodium citrate, pH 3.5. No preservative added. Reconstitute in sterile dH2O to a concentration of 0.1-1mg/ml. This solution can be diluted into other buffered solutions or stored at -20 degrees C for future use.

Purity

(same/more than) 98% by SDS-PAGE and HPLC. Endotoxin: (same/less than) 0.1ng/ ug (1EU/ug).