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Granzyme A

Cat no: G8956-08


Supplier: United States Biological
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The biological function of Granzyme A is unclear. It would appear that the molecule may have a role in the induction of apoptosis via its activity as a serine protease, but this would seem to be subsidiary to the role of Granzyme B. Granzyme A deficient mice are indistinguishable from normal animals in their response to infection. Cellular Localization: Secreted, Cytoplasmic granules. Applications: Suitable for use in Western Blot and Immunohistochemistry (paraffin-embedded sections). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G8956-08
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: 0.09% Sodium Azide; PBS
P type: Mab
Isotype: IgG1
Purity: Mouse ascites
References: Kummer JA et al. Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins. J Immunol Methods 163:77-83 (1993).
Additional info: Species Crossreactivity: Crossreacts with Human.Not yet tested in other species.

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