Granzyme B (C11, Cathespin G Like 1, CCPI,CGL 1, CGL1, CSP B, CSPB, CTLA 1, CTLA1, CTSGL 1,CTSGL1, Cytotoxic serine protease B, Cytotoxic T Lymphocyte Cytotoxic T lymphocyte proteinase 2, EC=3.4.21.79, Fragmentin 2, Granzyme 2, GRB, GZMB, HLP, Human lymph

Granzyme B is a cysteine protease found in the cytoplasmic lysosome-like granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells and is is required for the induction of target cell lysis. This occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms.\n\nCellular Localization: Cytoplasmic\n\nPositive Control: Tonsil\n\nApplications: \nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

G8957-06

Size

6ml

Applications

IHC

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

PBS with sodium azide

P Type

Pab

Purity

Purified

Isotype

IgG

Additional Info

This antibody reacts with a 32kD protein. Granzymes are neutral serine proteases, which are stored in specialized lytic granuels of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned. Human granzymes B is involved in target cell apoptosis during lymphocyte-mediated cytotoxicity. This antibody is useful in the localization of granzyme B containing lytic granules and for the characterization of activated CTLs or NK cells. This antibody crossreacts with mouse and rat. Species Crossreactivity: This antibody is reactive against Mouse and rat.

Alternative Names

C11, Cathespin G Like 1, CCPI, CGL 1, CGL1, CSP B, CSPB, CTLA 1, CTLA1, CTSGL 1, CTSGL1, Cytotoxic serine protease B, Cytotoxic T Lymphocyte Associated Serine Esterase 1, Cytotoxic T lymphocyte proteinase 2, EC=3.4.21.79, Fragmentin 2, Fragmentin2, Granzyme 2, Granzyme2, GranzymeB, GRB, GZMB, HLP, Human lymphocyte protein, Lymphocyte protease, Protease Serine B, SECT, T cell serine protease 1 3E