GRB2 (Abundant SRC homology, Adapter protein GRB2, ASH, Ash protein, EGFRBP GRB2, Epidermal growth factor receptor binding protein, Epidermal growth factor receptor binding protein GRB2, GRB 2, GRB2 adapter protein, Grb2, GRB2_HUMAN, Grb3 3, Growth Factor

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C. elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested. \n\nRecommended Dilution:\nWestern Blot: 1:500\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

143186

Size

100ul

Applications

WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat, NHP

Form

Supplied as a liquid in ascites fluid.

P Type

Mab

Purity

Ascites

Isotype

IgG1

Additional Info

Recognizes endogenous levels of GRB2. Does not cross-react with related proteins. Species Crossreactivity: human, rat, mouse, monkey

Alternative Names

(Abundant SRC homology, Adapter protein GRB2, ASH, Ash protein, EGFRBP GRB2, Epidermal growth factor receptor binding protein, Epidermal growth factor receptor binding protein GRB2, GRB 2, GRB2 adapter protein, Grb2, GRB2_HUMAN, Grb3 3, Growth Factor Receptor Bound Protein 2, Growth Factor Receptor Bound Protein 2, Growth factor receptor bound protein 3, Growth factor receptor-bound protein 2, HT027, MST084, MSTP084, OTTHUMP00000166096, OTTHUMP00000166097, OTTHUMP00000166098, Protein ASH, SEM5, SEM5, SH2/SH3 adapter GRB2)