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GRIA2

Cat no: 030274

GRIA2

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q:R and R:G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene.\n\nApplications:\nWestern Blot: 1:500-1:2000\nFlow Cytometry: 1:200-1:400\nELISA: 1:10000\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

030274

Size

100ul

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

Form

Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer\n<br>

P Type

Mab

Purity

Purified

Isotype

IgG1

References

1.Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Feb;24(4):173-6. \n2.Neurosci Lett. 2011 Jun 15;497(1):42-5.\n

Additional Info

Human

Alternative Names

GluA2; GluR2; gluR-B; GluR-K2

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