Grik4, NT (Glutamate receptor ionotropic kainate 4 precursor, EAA1, Excitatory amino acid receptor 1, Glutamate receptor KA-1, GRIK, KA1)

Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons (1,2). Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits (2,3). In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA- containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling (3). KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder (4,5). Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE.\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.5

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SPECIFICATIONS

Catalog Number

G4005-96A

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Tanaka K. Functions of glutamate transporters in the brain. Neurosci. Res. 2000; 37:15-9 2. Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res. 2006; 326:457-82. 3. Mayer ML. GRIK4 and the Kainate Receptor. Am. J. Psychiatry 2007; 164:1148. 4. Pickard BS, Malloy MP, Christoforou A, et al. Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. Mol. Psychiatry 2006; 11:847-57. 5. Blackwood DH, Pickard BJ, Thompson PA, et al. Are some genetic risk factors common to schizophrenia, bipolar disorder and depression? Evidence from DISC1, GRIK4 and NRG1. Neurotox. Res. 2007; 11:73-83.

Additional Info

Recognizes human Grik4. Species crossreactivity: Mouse and rat.