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GRIN2A (NMDAR2A, Glutamate [NMDA] Receptor Subunit epsilon-1, N-methyl D-aspartate Receptor Subtype 2A)

Cat no: 136905

GRIN2A (NMDAR2A, Glutamate [NMDA] Receptor Subunit epsilon-1, N-methyl D-aspartate Receptor Subtype 2A)

N-methyl-D-aspartate receptor (NMDAR) forms a heterodimer of at least one NR1 and one NR2A-D subunit. Multiple receptor isoforms with distinct brain distributions and functional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2 subunits. NR1 subunits bind the co-agonist glycine and NR2 subunits bind the neurotransmitter glutamate.\n\nNMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.\n\nApplications:\nSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:1000-1:2000\nImmunohistochemistry: 1:1000\nImmunoprecipitation: 3ul will (under appropriate conditions) quantitatively immunoprecipitate all NMDAR2A in 200mg of rat brain.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile dH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

136905

Size

100ul

Applications

IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Rat

Form

Supplied as a lyophilized powder. Reconstitute with sterile dH2O or PBS.

P Type

Pab

Purity

Serum

Isotype

IgG

Additional Info

Recognizes rat NMDA Receptor 2A. Species Crossreactivity: human.

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