GRM7, NT (GRM7, GPRC1G, MGLUR7, Metabotropic glutamate receptor 7) (FITC)

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze FITC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

036316-FITC

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to FITC.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)\nSaus, E., et al. J Psychiatr Res 44(14):971-978(2010)\nRose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :\nJoslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)\nSchulz, H.L., et al. Neurosci. Lett. 326(1):37-40(2002)

Additional Info

Human

Alternative Names

GRM7, GPRC1G, MGLUR7, Metabotropic glutamate receptor 7