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Growth Associated Protein 43, CT (GAP43, Neuromodulin, PP46, p57, B-50, F1, Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50)

Cat no: G8990-01C

Growth Associated Protein 43, CT (GAP43, Neuromodulin, PP46, p57, B-50, F1, Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50)

Growth associated protein GAP43 (B-50, F1, neuromodulin) is a phosphoprotein of the presynaptic membrane involved in synaptic reorganization and neural development. Phospholyated at Ser41 by protein kinase C (PKC), phospholyated GAP43 has been correlated to release of neurotransmitters in mature nervous system (1). Also, GAP43 plays an essential role in the maintenance mechanism of long-term potentiation (LTP) (2). These suggest GAP43 to play a role in synaptic plasticity. For neurons in development or regeneration, GAP43 is a major component of the growth cone, which enables elongation and navigation of developing axons (3). During periods of low activity in neurons, Calmodulin binds to GAP43 when Ca2+ is low, suggesting Calmodulin as a negative regulator of GAP43 (4).\n\nApplications: \nSuitable for use in Flow Cytometry, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: 1:50\nWestern Blot: 1:10,000\nImmunohistochemistry: 1:250

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SPECIFICATIONS

Catalog Number

G8990-01C

Size

100ul

Applications

FC, ICC, IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1.McIntosh H. et al. Visual Neuroscience. 2: 583-591, 1989. 2.Gianotti C, et al. Neuron 8: 843-8, 1992.\n3.Skene JH, et al. Science 233: 783-786, 1986. 4.Neve RL, et al. J Neuro 18: 7757-7767, 1998.

Additional Info

Recognizes human GAP-43

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