Growth Hormone, Recombinant, Chicken (Somatotropin, GH)

GH is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Growth Hormone Chicken Recombinant (cGH) produced in E. coli is a single, non-glycosylated, polypeptide chain containing 191aa with an additional Ala at its N-terminus and having a molecular mass of 22255D. GH Chicken recombinant is purified by proprietary chromatographic techniques.\n\nSource:\nRecombinant corresponding to chicken growth hormone expressed in E. coli.\n\nAA Sequence:\nAla-Thr-Phe-Pro-Ala\n\nMolecular Weight: \n~22.255kD\n\nBiological Activity: \nGH Chicken Recombinantis fully biologically active in homologous assays and in PDF-P1 3B9 cells stably transfected with rabbit GH receptors.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

G8989-95A

Size

50ug

Form

Supplied as a lyophilized powder from 0.3% sodium bicarbonate, pH 8. Reconstitute with sterile dH2O or 0.4% NaHCO3 adjusted to pH 8-9 to (same/more than)100ug/ml.

Purity

~99% (SDS-PAGE, HPLC)