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GRP94, Recombinant, Human (heat shock protein 90kD beta, Grp94, member 1, 94 kD glucose-regulated protein, ECGP, HSP90B1, Endoplasmin precursor, GP96, gp96 homolog, GRP94, Heat shock protein 90kD beta member 1, TRA1, Tumor Rejection Antigen 1)

Cat no: G3057-44C

GRP94, Recombinant, Human (heat shock protein 90kD beta, Grp94, member 1, 94 kD glucose-regulated protein, ECGP, HSP90B1, Endoplasmin precursor, GP96, gp96 homolog, GRP94, Heat shock protein 90kD beta member 1, TRA1, Tumor Rejection Antigen 1)

GRP94, also known as Heat shock protein 90kDa beta, member 1 (HSP90B1), is an abundant resident endoplasmic reticulum (ER) lumenal stress protein which together with cytosolic Hsp90 belongs to the Hsp90 family of molecular chaperones. It plays an important role in maintaining protein homeostasis in the secretory pathway. Also, GRP94 can function in the intracellular trafficking of peptides from the extracellular space to the MHC class I antigen processing pathway of antigen presentation cells. Recombinant human GRP94 protein, fused to His-tag at N-terminus.\n\nAA Sequence:\nMRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMDDE VDVDGTVEED LGKSREGSRT DDEVVQREEE AIQLDGLNAS QIRELREKSE KFAFQAEVNR\nMMKLIINSLY KNKEIFLREL ISNASDALDK IRLISLTDEN ALSGNEELTV KIKCDKEKNL LHVTDTGVGM TREELVKNLG TIAKSGTSEF LNKMTEAQED\nGQSTSELIGQ FGVGFYSAFL VADKVIVTSK HNNDTQHIWE SDSNEFSVIA DPRGNTLGRG TTITLVLKEE ASDYLELDTI KNLVKKYSQF INFPIYVWSS\nKTETVEEPME EEEAAKEEKE ESDDEAAVEE EEEEKKPKTK KVEKTVWDWE LMNDIKPIWQ RPSKEVEEDE YKAFYKSFSK ESDDPMAYIH FTAEGEVTFK\nSILFVPTSAP RGLFDEYGSK KSDYIKLYVR RVFITDDFHD MMPKYLNFVK GVVDSDDLPL NVSRETLQQH KLLKVIRKKL VRKTLDMIKK IADDKYNDTF\nWKEFGTNIKL GVIEDHSNRT RLAKLLRFQS SHHPTDITSL DQYVERMKEK QDKIYFMAGS SRKEAESSPF VERLLKKGYE VIYLTEPVDE YCIQALPEFD\nGKRFQNVAKE GVKFDESEKT KESREAVEKE FEPLLNWMKD KALKDKIEKA VVSQRLTESP CALVASQYGW SGNMERIMKA QAYQTGKDIS TNYYASQKKT\nFEINPRHPLI RDMLRRIKED EDDKTVLDLA VVLFETATLR SGYLLPDTKA YGDRIERMLR LSLNIDPDAK VEEEPEEEPE ETAEDTTEDT EQDEDEEMDV\nGTDEEEETAK ESTAEKDEL\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

G3057-44C

Size

20ug

Form

Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 1mM DTT, 1mM EDTA, 0.1M sodium chloride, 10% glycerol.

Purity

(same/more than) 90% (SDS-PAGE)

References

1. Randow F., et al. (2001). Nat Cell Biol. 3:E231. 2. Li Z., et al. (2002). Front Biosci. 7:d731-51

Alternative Names

HSP90B1, GP96, TRA1, Tumor rejection antigen 1

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