Glycogen synthase kinase-3 beta encoded by GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. Glycogen synthase kinase-3 beta is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in GSK3B have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for GSK3B.