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GSK3a, phosphorylated (Ser21) (Glycogen Synthase Kinase-3 alpha, GSK-3 alpha)

GSK3a, phosphorylated (Ser21) (Glycogen Synthase Kinase-3 alpha, GSK-3 alpha)

Cat no: G8170-43H

Supplier: United States Biological
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GSK3 is a serine/threonine kinase with a proline-directed substrate preference. Apart from phosphorylating and inhibiting glycogen synthase (GS), various other substrates for GSK3 have been identified that includes protein phosphatase inhibitor 2, ATP-citrate lyase, tau protein, beta-catenin, c-Myc, c-Jun, cAMP response element-binding protein, CCAAT/enhancer-binding protein- , and initiation factor eukaryotic initiation factor. In human, GSK3 exists in two isoforms a-isoform and b-isoform, encoded by two distinct genes located on chromosomes 19q13.1-2 and 3q13.3-q21, respectively. The a-isoform is a 51-53kD polypeptide, whereas the b-isoform is a 47kD polypeptide with 85% aa homology to GSK3a. GSK3a is an important regulator of muscle insulin action. The protein also plays a crucial role in the WNT and PI3K signaling pathways. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8170-43H
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Theodore, PC. et al. Endocrinology. 148:4393-4399 (2006).
Additional info: Recognizes human GSK3a, phosphorylated at Ser21. Species Crossreactivity: mouse and rat.

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