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GSK3b, phosphorylated (Tyr216) (Glycogen Synthase Kinase-3 beta, GSK-3 beta

GSK3b, phosphorylated (Tyr216) (Glycogen Synthase Kinase-3 beta, GSK-3 beta

Cat no: G8170-53K

Supplier: United States Biological
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GSK3b is a proline directed serine/threonine kinase, originally identified as a result of its role in glycogen metabolism regulation. GSK3b is particularly abundant in the central nervous system, where it is neuron specific. It affects many fundamental cellular functions, including cell cycle, gene transcription, and cytoskeletal integrity. GSK3b has recently been implicated in many signaling pathways, such as Wnt and PI3/PKB signaling. Recently the pathological role of the protein has been identified in Alzheimer Disease (AD), a neurodegenerative disease. Human GSK3b has been mapped to chromosomal region 3q13.3. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: 293 cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8170-53K
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Baolin, L. et al. Transgenic Research. 13:385-396 (2004).
Additional info: Recognizes human GSK3b, phosphorylated at Tyr216. Species Crossreactivity: mouse and rat.

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