GSR, CT (GSR, GLUR, GRD1, Glutathione reductase, mitochondrial) (PE)

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\nImmunohistochemistry: 1:10-50\nImmunofluorescence: 1:10-50\nFlow Cytometry: 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze R-Phycoerythrin conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

036334-PE

Size

200ul

Applications

ELISA, FC, IF, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Satoh, N., et al. Biochem. Genet. 48 (9-10), 816-821 (2010) :\nBailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)\nWang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)\nRose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :\nMoyer, A.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(3):811-821(2010)

Additional Info

Human

Alternative Names

GSR, GLUR, GRD1, Glutathione reductase, mitochondrial