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GST-mu, Recombinant, Human (Glutathione S Transferase mu, GSTmu)

Cat no: G8135-20K

GST-mu, Recombinant, Human (Glutathione S Transferase mu, GSTmu)

GST's are responsible for the metabolism of a broad range of xenobiotics and carcinogens. The enzyme catalyzes the reaction of glutathione with a wide variety of organic compounds to form thioethers, a reaction that is sometimes a first step in a detoxification process leading to mercapturic acid formation. Based on aa sequence similarities and antibody cross-reactivities, the mammalian cytosolic GSTs are divided into the following classes: alpha, mu, kappa, theta, pi, zeta, omega and sigma. GSTs exists as homodimers of ~25kD. GST A1-1 is mainly found in kidney, intestine, lung, and liver. GST M1-1 is restricted to liver and few other tissues. GST P1-1 has a widespread distribution in most tumor cells and tissues but it is absent in liver. The GST M1-1 is the type b allelic variant and corresponds to human GST Y.\n\nThe GST M1 along with GST M2-GST M5 are mapped to Chrm 1, There is a close physical proximity between GSTM1 and GSTM2 loci, which shares 99% nucleotide sequence identity over 460 nucleotides of 3-prime untranslated mRNA. The 181aa long GST M1 is mainly expressed in liver, brain, testis, kidney and lung and show enzyme activity towards CDNB; AFB1

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SPECIFICATIONS

Catalog Number

G8135-20K

Size

25ug

Applications

ELISA, WB

Form

Supplied as a liquid in 50mM Tris, pH7.5, 50mM sodium chloride; 1mM DTT, 1mM EDTA, 50% glycerol.

Purity

Highly Purified (~95%)

References

1. Knapen MFCM (200) Lancet, 355, 1463-1464. 2. Morel F et al (2002) Pharmacogenetics 12, 277- 286. 3. Suzuki T et al (1993) Genomics 18, 680-686.

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