GW182 Antibody

Cat no: 252026

Supplier: ABBIOTEC

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Description
Additional Information

Trinucleotide repeat-containing gene 6A protein (GW182) plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). GW182 is required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. Antibodies against GW182 are found in sera from patients with Sjoegren syndrome (SS), ata, Xenopus/Amphibian,ia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.

Catalogue number:	252026
Reactivities:	Human, Mouse, Rabbit
Applications:	Western Blot
Size:	0.1 mg
Accession:	Q8NDV7
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GW182.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Trinucleotide repeat-containing gene 6A protein; CAG repeat protein 26; Glycine-tryptophan protein of 182 kDa; GW182 autoantigen; Protein GW1; EMSY interactor protein; TNRC6A; CAGH26; KIAA1460; TNRC6