GW1929 (N-(2-Benzoylphenyl)-L-tyrosine PPARgamma Agonist, (2S)-((2-Benzoylphenyl)amino-3-phenyl]propionic acid)

Potent and subtype-selective (>1000-fold) PPARgamma agonist. Angiogenesis inhibitor. Apoptosis inhibitor. Anti-inflammatory. Anti-hyperglycemic and anti-hyperlipidemic agent. Antidiabetic. The glucose-lowering effect in rats is 100-fold more potent than that of troglitazone.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nStable for at least 2 years after receipt when stored at -20 degrees C. Store solutions at -20 degrees C in the dark.

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SPECIFICATIONS

Catalog Number

044874

Size

1mg

Purity

>98% (NMR)

References

Product Reference: \n?N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents: B.R. Henke, et al.; J. Med. Chem. 41, 5020 (1998)\n?A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat: K.K. Brown, et al.; Diabetes 48, 1415 (1999)\n?PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium: E. Scoditti, et al.; Cardiovasc. Res. 86, 302 (2010)\n?Ameliorative Effects of GW1929, a Nonthiazolidinedione PPAR gamma Agonist, on Inflammation and Apoptosis in Focal Cerebral Ischemic-Reperfusion Injury: R.K. Kaundal & S.S. Sharma; Curr. Neurovasc. Res. 8, 236 (2011)\n?

Alternative Names

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma Agonist, (2S)-((2-Benzoylphenyl)amino-3-phenyl]propionic acid