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GW2580, Free Base (5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine)

Cat no: G9951-25

GW2580, Free Base (5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine)

GW2580 is a small-molecule inhibitor of cFMS kinase; at 60nM it inhibited human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 inhibited lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse macrophages in vitro. Also, GW2580 at 1uM totally inhibited CSF-1-induced growth of mouse M-NFS-60 myeloid cells and human monocytes, and prevented bone degradation in cultures of rat calvaria and rat fetal long bone in vitro.\n\nMelting Point:\n209-210.5 degrees C\n\nElemental Analysis:\nCalculated\nC = 65.56%\nH = 6.05%\nN = 15.29%\n\nFound\nC = ~65%\nH = ~6%\nN = ~15%\n\nSolubility:\nSoluble in DMSO at 40mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-100uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.\n\nStorage and Stability:\nLong-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G9951-25

Size

100mg

Form

Supplied as an off-white powder

Purity

~99%

References

1. Conway, J.G., et al., Proc. Natl. Acad. Sci. USA 102: 16,078-16,083 (2005). 2. Conway, J.G., et al., J. Pharmacol. Exp. Ther. 326: 41-50 (2008).

Alternative Names

(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine)

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Applications

ELISA

Reactivities

Hum

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Applications

IF

Hosts

Mouse

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Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

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Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

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Applications

ELISA, FC, IHC, WB

Hosts

Mouse

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Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

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Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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