GYY 4137 (4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt)

Water-soluble, slow-releasing hydrogen sulfide (H2S) donor. Exhibits vasodilator and antihypertensive activity. Anti-inflammatory. Inhibits LPS-induced release of proinflammatory mediators (IL-1beta, IL-6, TNF-alpha, nitric oxide (NO) and PGE2) and increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-kappaB, ATF-2 and HSP27 dependent pathways. Causes stomatal opening and reduces nitric oxide accumulation in plants. Oxidative stress-induced cell death inhibitor. Shows novel anti-cancer effects in vitro and in vivo. Anti-thrombotic via p-selectin dependent mechanism.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nStable for at least 2 years after receipt when stored at -20 degrees C. Store solutions at -20 degrees C in the dark.

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SPECIFICATIONS

Catalog Number

044875

Size

10mg

Purity

>95% (NMR)

References

Product Reference: \n?Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.: L. Li et, al.; Circulation 117, 2351 (2008)\n?GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat.: L. Li, et al.; Free Radic. Biol. Med. 47, 103 (2009)\n?The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages: M. Whiteman, et al.; Antioxid. Redox Signal. 12, 1147 (2010)\n?Hydrogen sulfide and its modulation in arterial hypertension and atherosclerosis: J. BeЕ‚towski, et al.; Cardiovasc. Hematol. Agents Med. Chem. 8, 173 (2010)\n?A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation: M. Lisjak, et al.; Plant Physiol. Biochem. 48, 931 (2010)\n?Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is h(2) S a novel cytoprotective mediator in the inflamed joint?: B. Fox, et al.; J. Cell. Mol. Med. (Epub ahead of print) (2011)\n?The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo: Z.W. Lee, et al.; PLOS One 6, e21077 (2011)\n?The slow releasing H2S donor GYY 4137 exerts anti-thrombotic effects via a P-selectin dependent mechanism: E. Grambow, et al.; DGCH M

Alternative Names

4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt