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H-8 dihydrochloride (N-5-isoquinolinesulfonamide . 2HCl)

Cat no: 044876


Supplier: United States Biological
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Potent cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Myosin light chain kinase (MLCK) inhibitor. Tool to study protein crystal structure-inhibitor interactions. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: +4 degrees C Stable for at least 2 years after receipt when stored at +4 degrees C.
Catalogue number: 044876
Size: 10mg
Purity: >98% (NMR)
Alternative names: N--5-isoquinolinesulfonamide . 2HCl
References: Product Reference: ?Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C: H. Hidaka, et al.; Biochemistry 23, 5036 (1984) ?Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors: M. Inagaki, et al.; Mol. Pharmacol. 29, 577 (1986) ?Specific binding of a novel compound, N--5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase: M. Hagiwara, et al.; Mol. Pharmacol. 31, 523 (1987) ?Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives: M. Hagiwara, et al.; Mol. Pharmacol. 32, 7 (1987) ?Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity: R.A. Engh, et al.; J. Biol. Chem. 271, 26157 (1996) ?

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