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Products H-89 dihydrochloride (N-5-isoquinolinesulfonamide . 2HCl)
| Catalogue number: | 044877 |
| Size: | 1mg |
| Purity: | >98% (NMR) |
| Alternative names: | N--5-isoquinolinesulfonamide . 2HCl |
| References: | Product Reference: ?Polyamines differentially inhibit cyclic AMP-dependent protein kinase-mediated phosphorylation in the brain of the tobacco hornworm, Manduca sexta.: W.L. Combest et al.; J. Neurochem. 51, 1581 (1988) ?Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N--5-isoquinolinesulfonamide (H-89), of PC12: T. Chijiwa et al.; J. Biol. Chem. 265, 5267 (1990) ?A selective inhibitor of cyclic AMP-dependent protein kinase, N--5- isoquinolinesulfonamide (H-89), inhibits phosphatidylcholine biosynthesis in HeLa cells: C.C. Geilen et al.; FEBS Lett. 309, 381 (1992) ?Characterization of activators and inhibitors of protein kinase C mu: F.J. Johannes et al.; Eur. J. Biochem. 227, 303 (1995) ?Protein kinase A inhibitors enhance radiation-induced apoptosis: D. Findik et al.; J. Cell Biochem. 57, 12 (1995) ?Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity: R.A. Engh et al.; J. Biol. Chem. 271, 26157 (1996) ?The protein kinase A inhibitor H89 acts on cell morphology by inhibiting Rho kinase: J. Leemhuis, et al.; J. Pharmacol. Exp. Ther. 300, 1000 (2002) ?H89 (N--5-isoquinolinesulfonamide) induces reduction of myosin regulatory light chain phosphorylation and inhibits cell proliferation: D. Umeda, et al.; Eur. J. Pharmacol. 590, 61 (2008) ?The many faces of H89: a review: A. Lochner & J.A. Moolman; Cardiovasc. Drug Rev. 24, 261 (2006) ? |
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