H-89 dihydrochloride (N-5-isoquinolinesulfonamide . 2HCl)

Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Protein kinase Cmicro (PKCmicro) inhibitor. Ca2+/calmodulin-dependent protein kinase II inhibitor. Casein kinase I inhibitor. Myosin light chain kinase (MLCK) inhibitor. Apoptosis enhancer. Tool to study protein crystal structure-inhibitor interactions. Rho kinase inhibitor. Cell proliferation inhibitor. Review.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: +4 degrees C\nStable for at least 2 years after receipt when stored at +4 degrees C.

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SPECIFICATIONS

Catalog Number

044877

Size

1mg

Purity

>98% (NMR)

References

Product Reference: \n?Polyamines differentially inhibit cyclic AMP-dependent protein kinase-mediated phosphorylation in the brain of the tobacco hornworm, Manduca sexta.: W.L. Combest et al.; J. Neurochem. 51, 1581 (1988) \n?Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N--5-isoquinolinesulfonamide (H-89), of PC12: T. Chijiwa et al.; J. Biol. Chem. 265, 5267 (1990)\n?A selective inhibitor of cyclic AMP-dependent protein kinase, N--5- isoquinolinesulfonamide (H-89), inhibits phosphatidylcholine biosynthesis in HeLa cells: C.C. Geilen et al.; FEBS Lett. 309, 381 (1992) \n?Characterization of activators and inhibitors of protein kinase C mu: F.J. Johannes et al.; Eur. J. Biochem. 227, 303 (1995) \n?Protein kinase A inhibitors enhance radiation-induced apoptosis: D. Findik et al.; J. Cell Biochem. 57, 12 (1995) \n?Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity: R.A. Engh et al.; J. Biol. Chem. 271, 26157 (1996) \n?The protein kinase A inhibitor H89 acts on cell morphology by inhibiting Rho kinase: J. Leemhuis, et al.; J. Pharmacol. Exp. Ther. 300, 1000 (2002) \n?H89 (N--5-isoquinolinesulfonamide) induces reduction of myosin regulatory light chain phosphorylation and inhibits cell proliferation: D. Umeda, et al.; Eur. J. Pharmacol. 590, 61 (2008) \n?The many faces of H89: a review: A. Lochner & J.A. Moolman; Cardiovasc. Drug Rev. 24, 261 (2006) \n?

Alternative Names

N--5-isoquinolinesulfonamide . 2HCl