HADH2, aa12-261, Recombinant, Human (Hydroxyacyl-Coenzyme A Dehydrogenase Type II, Type II HADH, AB-binding Alcohol Dehydrogenase, ABAD, CAMR, DUPXp11.22, ERAB, HCD2, HSD17B10, MHBD, Mitochondrial Ribonuclease P Protein 2, MRPP2, MRX17, MRX31, MRXS10, SCH

HSD17B10 is a member of the short-chain dehydrogenase/reductase superfamily. This mitochondrial protein catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. HSD17B10 plays an important role in processing steroid hormones and fats, and also helps break down the protein building block (amino acid) isoleucine. This enzyme is also necessary for several chemical reactions involving female sex hormones (estrogens) and male sex hormones (androgens). It is essential for maintaining appropriate levels of male and female sex hormones. This protein may contribute to the neuronal dysfunction associated with Alzheimer disease. Recombinant HSD17B10 protein was expressed in E. coli.\n\nSource: \nRecombinant corresponding to aa12-261 of human HSD17B10 6x His tagged expressed in E. coli.\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MVAVITGGAS GLGLATAERL VGQGASAVLL DLPNSGGEAQ AKKLGNNCVF APADVTSEKD VQTALALAKG KFGRVDVAVN CAGIAVASKT YNLKKGQTHT LEDFQRVLDV NLMGTFNVIR LVAGEMGQNE PDQGGQRGVI INTASVAAFE GQVGQAAYSA SKGGIVGMTL PIARDLAPIG IRVMTIAPGL FGTPLLTSLP EKVCNFLASQ VPFPSRLGDP AEYAHLVQAI IENPFLNGEV IRLDGAIRMQ P\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

H1500-03

Size

100ug

Applications

WB

Form

Supplied as a liquid in 20mM Tris HCl, pH 8.0, 1mM DTT, 100mM NaCl, 10% glycerol.

Purity

~ 95% (SDS-PAGE). Purified by using conventional chromatography techniques.

References

1. Hoizmann J., et al. (2008) Cell. 135(3):462-74. 2. Yan SD., et al. (1997) Nature. 389(6652):689-95.

Alternative Names

3-hydroxyacyl-CoA Dehydrogenase Type 2, 3-hydroxyacyl-CoA Dehydrogenase Type II, 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase, 17beta-hydroxysteroid Dehydrogenase 10, EC=1.1.1.35, EC=1.1.1.178, Endoplasmic Reticulum-associated Amyloid beta Peptide Binding Protein, Hydroxyacyl CoA Dehydrogenase Type II, Hydroxysteroid (17-beta) Dehydrogenase 10, Mitochondrial RNase P Protein 2, Short Chain Dehydrogenase/reductase Family 5C Member 1, Short-chain Type Dehydrogenase/reductase XH98G2