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HAND1, Recombinant, Human, aa1-215, His-Tag (Heart- and Neural Crest Derivatives-expressed Protein 1, bHLHa27, eHand, Hxt, Thing1)

Cat no: 138662

HAND1, Recombinant, Human, aa1-215, His-Tag (Heart- and Neural Crest Derivatives-expressed Protein 1, bHLHa27, eHand, Hxt, Thing1)

HAND1 belongs to the basic helix-loop-helix family of transcription factors. This protein is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. \n\nSource:\nRecombinant protein corresponding to aa1-215 from human HAND1 at N-terminal, fused to His-tag expressed in E.coli. \n\nMolecular Weight: \n~26kD (238aa)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGS\nAATAYGPDAR PGQSPGRLEA LGGRLGRRKG SGPKKERRRT ESINSAFAEL RECIPNVPAD TKLSKIKTLR LATSYIAYLM DVLAKDAQSG DPEAFKAELK KADGGRESKR KRELQQHEGF PPALGPVEKR IKGRTGWPQQ VWALELNQ MNLVGSY AHHHHHHHPH PAHPMLHEPF LFGPASRCHQ ERPYFQSWLL SPADAAPDFP AGGPPPAAAA\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

138662

Size

100ug

Form

Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 0.4M urea, 10% glycerol.

Purity

~90% (SDS-PAGE)

References

1, Scott IC., et al. (2000). Mol Cell Biol. 20(2):530-41. 2. Srivastava D. Trends Cardiovasc Med. 1999 Jan-Feb;9(1-2):11-8.

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