Haptoglobin

Haptoglobin is a serum alpha-2-glycoprotein that exists as a tetramer, composed of two smaller identical alpha chains and two larger identical beta chains. The a-chains are linked to each other by a disulfide bond and each b-chain is similarly linked to the a-chains. Plasma haptoglobin is structurally similar to serum immunoglobulins. Normal adult plasma contains at least three different haplotypes; based on their differences in light a-subunit structure: Type 1-1 and Type 2-2 have homozygous a-1 (9kD) and a-2 (18kD) subunits. Type 2-1 has hetrozygous a-1 and a-2 subunits, with a common b-subunit in all three haplotypes (38kD). Haptoglobin

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SPECIFICATIONS

Catalog Number

H1820-05

Size

100ul

Applications

ELISA

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid, 15mM sodium azide.

P Type

Mab

Purity

Ascites

Isotype

IgG1

Additional Info

Recognizes the three types of human haptoglobin (Types 1-1, 2-1, 2-2). By ELISA, recognizes human haptoglobin as the purified antigen and in serum when complexed with human hemoglobin or captured by antibodies. Reacts against native and denatured (non-reduced) human haptoglobin in a Western Blot or Dot Blot. Fails to recognize the different haptoglobin type under reducing conditions. Does not crossreact with human IgG, transferrin, CRP, alpha-1-acid glycoprotein, albumin or hemoglobin, nor with bovine, goat or sheep serum as determined by competitive ELISA.