HAVCR2 (Hepatitis A Virus Cellular Receptor 2, HAVcr-2, T-cell Immunoglobulin and Mucin Domain-containing Protein 3, TIMD-3, T-cell Membrane Protein 3, TIM-3, TIM3, TIMD3)

HAVCR2 is a 281aa Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. It consists of an IgV-region like domain and a mucin-like domain in the extracellular region and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. HAVCR2 regulates macrophage activation thereby down regulating aggressive Th-1 mediated immune responses and facilitates in the development of immune tolerance. It plays an important role in the induction of autoimmune diseases by regulating macrophage activation. Pathological significance of HAVCR2 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1-3ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nMouse or rat kidney cell lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

H1900-34B

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Mouse

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by Protein G affinity Chromatography.

Isotype

IgG

References

1. McIntire,J.J., Umetsu,S.E., Akbari,O., Potter,M., Kuchroo,V.K., Barsh,G.S., Freeman,G.J., Umetsu,D.T. and DeKruyff,R.H. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat. Immunol. 2 (12), 1109-1116 (2001). 2. Monney,L., Sabatos,C.A., Gaglia,J.L., Ryu,A., Waldner,H., Chernova,T., Manning,S., Greenfield,E.A., Coyle,A.J., Sobel,R.A., Freeman,G.J. and Kuchroo,V.K. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415 (6871), 536-541 (2002). 3. Sanchez-Fueyo A et.al Nat Immunol. 4(11):1093-101 (2003 Nov) 4. Soo-Cheon Chae et.al Immunology Letters 95 (1): 91-95 (15 Aug 2004).

Additional Info

Recognizes mouse HAVCR2. Species sequence homology: rat.