HAX1, CT (HAX1, HS1BP1, HCLS1-associated protein X-1, HS1-associating protein X-1, HS1-binding protein 1) (PE)

The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\nImmunohistochemistry: 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze R-Phycoerythrin conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

036443-PE

Size

200ul

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Johns, H.L., et al. J. Gen. Virol. 91 (PT 11), 2677-2686 (2010) :\nMekkawy, A.H., et al. Biochem. Biophys. Res. Commun. 399(4):738-743(2010)\nHan, J., et al. J. Biol. Chem. 285(29):22461-22472(2010)\nGermeshausen, M., et al. Haematologica 95(7):1207-1210(2010)\nBurnicka-Turek, O., et al. BMC Cell Biol. 11, 28 (2010) :

Additional Info

Human

Alternative Names

HAX1, HS1BP1, HCLS1-associated protein X-1, HS1-associating protein X-1, HS1-binding protein 1