HB-EGF, Recombinant, Human (Heparin Binding EGF-like growth factor, HBEGF, Diphtheria toxin receptor, DTR)

Supplier:

United States Biological

Cat no: 143353

HB-EGF, Recombinant, Human (Heparin Binding EGF-like growth factor, HBEGF, Diphtheria toxin receptor, DTR)

HB-EGF is an EGF related growth factor that signals through the EGF receptor, and stimulates the proliferation of smooth muscle cells (SMC), fibroblasts, epithelial cells, and keratinocytes. HB-EGF is expressed in numerous cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes, and certain tumor cells. The ability of HB-EGF to specifically bind heparin and heparin sulfate proteoglycans is distinct from other EGF-like molecules, and may be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells. The human HB-EGF gene encodes a 208 amino acid transmembrane protein, which can be proteolytically cleaved to produce soluble HB-EGF. Recombinant human HB-EGF is a 9.7kD protein containing 86 amino acid residues, corresponding to the extra-cellular EGF-like and heparin binding domains of the full length HB-EGF protein.\n\nBiological Activity:\nThe ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ~1.0ng/ml, corresponding to a specific activity of ~1x10e6 units/mg.\n\nAA Sequence:\nDLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLG KKRDPCLRKY KDFCIHGECKYVKELRAPSC ICHPGYHGER CHGLSL\n\nQuality Control:\nVerified by N-terminal and Mass Spectrometry analyses (when applicable).\n\nEndotoxin:\n<0.1ng/ug of protein (<1EU/ug).\n\nProtein Content:\nVerified by UV Spectroscopy and/or SDS-PAGE gel.\n\nStorage and Stability:\nStore lyophilized products at -20 degrees C. For reconstituted solutions of most products, we recommend short-term storage at 4 degrees C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20 degrees C. Additional freeze/thaw cycles may cause some denaturation of the protein.

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SPECIFICATIONS

Catalog Number

143353

Size

10ug

Form

Supplied as a lyophilized powder.

Purity

(same/more than)95% by SDS-PAGE gel and HPLC analyses.

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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