Host Cell Proteins (HCP) are a very important class of impurities in the biopharmaceutical process. When host cells such as E. coli, yeast, mammalian cells, etc., are used to produce recombinant proteins or other biologics, their own proteins may mix with the target product. These residual HCPs can not only affect the safety and efficacy of drugs but may also provoke adverse reactions or immune responses.
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