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MtoZ Biolabs

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HCV-NS3 Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 250686

HCV-NS3 Antibody

Hepatitis C virus (HCV) helicase (non-structural protein 3, NS3) is involved in HCV genome replication and is considered a target for inhibition of HCV. Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. The protease is self-inactivated following maturation. NS3 has three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease in association with NS4A is responsible for the cleavages of NS3-NS4A, NS4A-NS4Bovine, NS4B-NS5A and NS5A-NS5B. NS3/NS4A comple, Xenopus/Amphibian, also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. NS3 cleaves and inhibits the host antiviral protein MAVS.

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SPECIFICATIONS

Catalog Number

250686

Size

0.1 mg

Applications

IHC

Reactivities

Hum

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N/C-term region of human protein.

Isotype

Rabbit Ig

Accession

P26663

Additional Info

Genome polyprotein hepatitis virus C; Helicase NS3; Non-structural protein 3; Hepacivirin; NS3P; p70

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