HDAC3, CT (HDAC3, Histone deacetylase 3, RPD3-2, SMAP45)

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq].\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\nImmunohistochemistry: 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

036478

Size

200ul

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Minamiya, Y., et al. Tumour Biol. 31(5):533-539(2010)\nKim, H.C., et al. Cell. Mol. Life Sci. 67(20):3499-3510(2010)\nYang, Z., et al. Clin. Chem. Lab. Med. (2010) In press :\nKim, T., et al. Psychiatry Res 178(2):266-269(2010)\nAdams, H., et al. Expert Opin. Ther. Targets 14(6):577-584(2010)

Additional Info

Human

Alternative Names

HDAC3, Histone deacetylase 3, RPD3-2, SMAP45