HDAC7 (Phospho-Ser155) Polyclonal Antibody

Antigen: synthetic peptide from human HDAC7 containing phospho-Ser155 . Host: rabbit . Cross Reactivity: (+) chimpanzee, bovine, canine, human, monkey, mouse, and rat HDAC7 . Application(s): WB . HDAC7 is a class IIa HDAC that plays a specific role in maintaining vascular integrity by repressing the expression of matrix metalloproteinase 10. It promotes repression mediated by transcriptional corepressor NCOR2 and is an efficient corepressor of the androgen receptor. It is also responsible for the deacetylation of lysine residues on the N-terminal part of the core histones.

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SPECIFICATIONS

Catalog Number

13500

Applications

WB

Hosts

Rabbit

Form

1 ea

P Type

Histone Deacetylase|Antibodies

Weight

0

Antigen

synthetic peptide from human HDAC7 containing phospho-ser155

Storage Temp

-20

Shipping Temp

-20

Additional Info

Histone deacetylase 7 (HDAC7) is a thymus-specific, intracellular transcription factor belonging to the class IIa HDAC family. Reports suggest that dephosphorylation and nuclear localization of HDAC7 is promoted by myosin phosphatase, thus regulating the repression of Nur77 and inhibition of apoptosis in CD4+/CD8+ double-positive thymocytes. HDAC7 plays a specific role in maintaining vascular integrity by repressing the expression of matrix metalloproteinase (MMP) 10. It promotes repression mediated by transcriptional corepressor NCOR2 and is an efficient corepressor of the androgen receptor (AR). It is also responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4).