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Hepatitis C Virus NS3, aa1192-1459, Recombinant (HCV)

Cat no: 138017

Hepatitis C Virus NS3, aa1192-1459, Recombinant (HCV)

HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes (1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6).\n\nSource:\nRecombinant protein corresponding to aa1192-1459 of HCV NS3 immunodominant regions of Hepatitis C Virus protein, expressed in E.coli.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

138017

Size

100ug

Form

Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 20mM beta mercaptoethanol.

Purity

~90% (SDS-PAGE)

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