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HES1, Recombinant, Human (His) (Hairy and Enhancer of Split 1, Transcription Factor HES-1, Class B Basic Helix-loop-helix Protein 39, bHLHb39, Hairy Homolog, Hairy-like Protein, HRY, hHL)

Cat no: 044884

HES1, Recombinant, Human (His) (Hairy and Enhancer of Split 1, Transcription Factor HES-1, Class B Basic Helix-loop-helix Protein 39, bHLHb39, Hairy Homolog, Hairy-like Protein, HRY, hHL)

bHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 (Hairy and Enhancer of Split 1) is a basic Helix-Loop-Helix (bHLH) transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signaling plays both oncogenic and tumor suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target HES1 is sufficient to reproduce this tumor suppressor phenotype in B-ALL by interacting and activating PARP-1 and regulating proapoptotic signals.\n\nSequence:\nHuman HES1 (aa 2-280) is fused at the N-terminus to a His-tag.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nWorking aliquots are stable for up to 3 months when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

044884

Size

10ug

Form

Supplied as a liquid from a 0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, 150mM NaCl.

Purity

>90% (SDS-PAGE)

Alternative Names

Hairy and Enhancer of Split 1, Transcription Factor HES-1, Class B Basic Helix-loop-helix Protein 39, bHLHb39, Hairy Homolog, Hairy-like Protein, HRY, hHL

Read more on Supplier website

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

More info

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

More info
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