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HIF1A Polyclonal Antibody

Cat no: CAC07003

HIF1A Polyclonal Antibody

HIF1A Polyclonal Antibody

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SPECIFICATIONS

Price

323.00 USD

Catalog Number

CAC07003

Size

100 micro g

Applications

IHC, WB

Hosts

Rabbit

Conjugates

Unconj

Purity

Caprylic Acid Ammonium Sulfate Precipitation Purified

Target

HIF1A

Clonality

Polyclonal

Storage Temp

Aliquot and store at -20 degrees C. Minimize freezing and thawing.

Research Area

For research use only. Not for diagnostic procedures.

Shipping Temp

Blue ice

Additional Info

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.

Alternative Names

ARNT-interacting protein,Basic-helix-loop-helix-PAS protein MOP1,Class E basic helix-loop-helix protein 78,Member of PAS protein 1,PAS domain-containing protein 8.HIF1A, BHLHE78, MOP1, PASD8

SUPPLIER INFO

Biomatik Corporation

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