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HIV-1 gp41 Antibody

HIV-1 gp41 Antibody

Cat no: 250695

Supplier: ABBIOTEC
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The transmembrane protein gp41 (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state,Porcinere-hairpin intermediate state, and post-fusion hairpin state. During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure,Porcineositioning the fusion peptide in close pro, Xenopus/Amphibian,imity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane. The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface e, Xenopus/Amphibian,posure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm. The gp120-gp41 heterodimer seems to contribute to T-cell depletion during HIV-1 infection.
Catalogue number: 250695
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: P04578
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term of HIV-1 gp41.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit IgG
Additional info: Envelope glycoprotein gp160; Env polyprotein; Transmembrane protein; TM; Glycoprotein 41; gp41; Human immunodeficiency virus type 1; HIV-1
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