HMG2, Recombinant, Human, aa1-209, His-tag (High-mobility Group Box 2, High Mobility Group Protein B2, High Mobility Group Protein 2, HMG2, HMG-2, HMGB2)

Supplier:

United States Biological

Cat no: H6202-20G

HMG2, Recombinant, Human, aa1-209, His-tag (High-mobility Group Box 2, High Mobility Group Protein B2, High Mobility Group Protein 2, HMG2, HMG-2, HMGB2)

High mobility group protein B2, also known as HMGB2, is a member of the non-histone chromosomal high-mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. Purified by using conventional chromatography techniques.\n\nSource:\nRecombinant corresponding to aa1-209 of human HMGB2 protein, fused to His-tag at N-terminus, expressed in Baculovirus.\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH TGSMGKGDPN KPRGKMSSYA FFVQTCREEH KKKHPDSSVN FAEFSKKCSE RWKTMSAKEK SKFEDMAKSD KARYDREMKN YVPPKGDKKG KKKDPNAPKR PPSAFFLFCS EHRPKIKSEH PGLSIGDTAK KLGEMWSEQS AKDKQPYEQK AAKLKEKYEK\nDIAAYRAKGK SEAGKKGPGR PTGSKKKNEP EDEEEEEEEE DEDEEEEDED EE\n\nMolecular Weight: \n~26.4 kDa (232aa)\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

H6202-20G

Size

100ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8, 1mM DTT, 0.1M sodium chloride, 30% glycerol.

Purity

~90% (SDS-PAGE)

References

Bustin M., et al. (1990) Biochem Biophys Acta. 1049:231-243. Shirakawa H., et al. (1992) J Biol Chem. 267:6641-6635.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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