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Products HMGB1 Monoclonal Antibody (Clone IMG19N15F4)
| Catalogue number: | 11513 |
| Hosts: | Mouse |
| Applications: | Flow Cytometry, Immunohistochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | full length recombinant human HMGB1 |
| P type: | Antibodies|Nuclear Receptors|Intracellular Signaling |
| Isotype: | IgG1? |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | High Mobility Group Protein B1 (HMGB1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury. |
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