HNE (4-Hydroxy-2-nonenal), ELISA Control (BSA)

Supplier:

United States Biological

Cat no: H6276-05B

HNE (4-Hydroxy-2-nonenal), ELISA Control (BSA)

HNE is a major product of endogenous lipid peroxidation. The w-6-family (linoleic and arachidonic acids) of polyunsaturated fatty acids may produce HNE as a result of free radical attack. HNE is a highly reactive compound and it can react with several functional groups on biological material, particularly sulfydryl groups to form thioester adduct and then hemiacetals. HNE may also react with histidine and lysine residues of proteins to form stable Michael addition-type of adducts. HNE-modified proteins may display an altered biological functions. Antibodies to HNE will help to visualize the HNE-adducts.

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SPECIFICATIONS

Catalog Number

H6276-05B

Size

50ug

Applications

ELISA, WB

Form

Supplied as a liquid in PBS. Conjugated to BSA.

Purity

Purified

References

1. Floyd, R.A. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J. 4, 2587-2597 (1990). 2. Taddei, F., Hayakawa, H., Bouton, M.-F., et al. Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science 278, 128-130 (1997).c3. Mo, Y., Maki, H., and Sekiguchi, M. Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: Sanitization of necleotide pool. Proc. Natl. Acad. Sci. USA 89, 11021-11025 (1992).c4. Lin, T.-S., Cheng, J.-C., Ishiguro, K., et al. 8-Substituted guanosine and 2

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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