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hnRNP A2/B1 (Heterogeneous Nuclear Ribonucleoproteins A2/B1, HNRNPA2B1, HNRPA2B1, HNRNPA2, HNRPA2, HNRNPB1, HNRPB1, DKFZp779B0244, FLJ22720, RNPA2, SNRPB1) (Azide Free)

Cat no: H6282-20C

hnRNP A2/B1 (Heterogeneous Nuclear Ribonucleoproteins A2/B1, HNRNPA2B1, HNRPA2B1, HNRNPA2, HNRPA2, HNRNPB1, HNRPB1, DKFZp779B0244, FLJ22720, RNPA2, SNRPB1) (Azide Free)

Heterogeneous nuclear ribonucleoproteins (hnRNP) bind to nascent RNA polymerase II transcripts and are involved in transcript-specific packaging as well as alternative splicing of pre-mRNAs. hnRNPs also appear to influence mRNA metabolism and transport. In vivo, the M proteins bind to mRNA, and in vitro they bind avidly to poly(G) and poly(U) homopolymers. Four different isoforms of hnRNP are produced by alternative splicing: M1, M2, M3 and M4. Ongoing studies have theorized that hnRNPs may cause certain genetic diseases such as myotonic dystrophy, which is the most common form of adult muscular dystrophy. The identification of hnRNPs may therefore be important to determining the cause and cure for genetic diseases.\n\nApplications: \nSuitable for use in ELISA, Immunofluorescence and Western Blot. Other applications not tested.\n\nRecommended Dilutions:\nELISA: 1-3ug/ml\nImmunofluorescence: 20ug/ml\nWestern Blot: 1:500-1:1000\nOptimal dilutions to be determined by the researcher.\n\nHybridoma: \nSp2/0 myeloma cells with spleen cells from Balb/c mice.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

H6282-20C

Size

100ul

Applications

ELISA, IF, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. No preservative added

P Type

Mab

Purity

Purified by ammonium sulfate precipitation.

Isotype

IgG1,k

Additional Info

Recognizes human HNRPA2B1.

Alternative Names

Heterogeneous Nuclear Ribonucleoprotein A2, Heterogeneous Nuclear Ribonucleoprotein B1

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